[HTML][HTML] Sex, gender, and sex hormones in pulmonary hypertension and right ventricular failure

J Hester, C Ventetuolo, T Lahm - Comprehensive Physiology, 2019 - ncbi.nlm.nih.gov
Pulmonary hypertension (PH) encompasses a syndrome of diseases that are characterized
by elevated pulmonary artery pressure and pulmonary vascular remodeling and that …

Current understanding of the right ventricle structure and function in pulmonary arterial hypertension

D Sharifi Kia, K Kim, MA Simon - Frontiers in physiology, 2021 - frontiersin.org
Pulmonary arterial hypertension (PAH) is a disease resulting in increased right ventricular
(RV) afterload and RV remodeling. PAH results in altered RV structure and function at …

[HTML][HTML] Molecular mechanisms of right ventricular dysfunction in pulmonary arterial hypertension: focus on the coronary vasculature, sex hormones, and glucose/lipid …

V Agrawal, T Lahm, G Hansmann… - … Diagnosis and Therapy, 2020 - ncbi.nlm.nih.gov
Pulmonary arterial hypertension (PAH) is a rare, life-threatening condition characterized by
dysregulated metabolism, pulmonary vascular remodeling, and loss of pulmonary vascular …

Hemodynamic function of the right ventricular-pulmonary vascular-left atrial unit: normal responses to exercise in healthy adults

SP Wright, TG Dawkins, ND Eves… - American Journal …, 2021 - journals.physiology.org
With each heartbeat, the right ventricle (RV) inputs blood into the pulmonary vascular (PV)
compartment, which conducts blood through the lungs at low pressure and concurrently fills …

Exogenous estrogen preserves distal pulmonary arterial mechanics and prevents pulmonary hypertension in rats

JL Philip, DM Tabima, GD Wolf, AL Frump… - American Journal of …, 2020 - atsjournals.org
17b-estradiol (E2), the most abundant female sex steroid, has been implicated in the
development and progression of pulmonary arterial hypertension (PAH)(1, 2). Although …

Pulmonary vascular mechanical consequences of ischemic heart failure and implications for right ventricular function

JL Philip, TM Murphy, DA Schreier… - American Journal …, 2019 - journals.physiology.org
Left heart failure (LHF) is the most common cause of pulmonary hypertension, which confers
an increase in morbidity and mortality in this context. Pulmonary vascular resistance has …

Effects of nitric oxide inhalation on pulmonary arterial impedance: Differences between normal and pulmonary hypertension male rats

M Fukumitsu, T Kawada, T Nishikawa… - American Journal …, 2024 - journals.physiology.org
Nitric oxide (NO) inhalation improves pulmonary hemodynamics in participants with
pulmonary arterial hypertension (PAH). Although it can reduce pulmonary vascular …

Targeting myadm to intervene pulmonary hypertension on rats before pregnancy alleviates the effect on their offspring's cardiac-cerebral systems

J Wang, Z Zhang, C Liang, T Lv, H Yu, S Ren… - Frontiers in …, 2022 - frontiersin.org
Pregnancy with pulmonary hypertension (PH) seriously threatens the life and safety of
mothers and infants. Here, the long-term effect of maternal PH on the postpartum growth of …

Wave reflection correlates with pulmonary vascular wall thickening in rats with pulmonary arterial hypertension

M Fukumitsu, T Kawada, S Shimizu, MJ Turner… - International Journal of …, 2017 - Elsevier
Background Wave reflection is enhanced in patients with pulmonary arterial hypertension
(PAH), which may be derived from a mismatch of pulmonary artery (PA) impedance between …

Sex Differences in Pulmonary Hypertension and Associated Right Ventricular Dysfunction

J Ma, N Owunna, N Jiang, X Huo, EK Zern, J McNeill… - medRxiv, 2024 - medrxiv.org
Background: Prior studies have established the impact of sex differences on pulmonary
arterial hypertension (PAH). However, it remains unclear whether these sex differences …