Protein glycosylation involves the co-translational or post-translational addition of glycans to
proteins and is a crucial protein modification in health and disease. The aim of …

The optical microscope has revolutionized biology since at least the 17th Century. Since
then, it has progressed from a largely observational tool to a powerful bioanalytical platform …

N-Glycoproteomics, the system-wide study of glycans asparagine-linked to protein carriers,
holds a unique and still largely untapped potential to provide deep insights into the …

The surface of all living cells is decorated with carbohydrate molecules. Hundreds of
functional proteins bind to these glycosylated ligands; such binding events subsequently …

Despite ground-breaking innovations in experimental structural biology and protein structure
prediction techniques, capturing the structure of the glycans that functionalize proteins …

Selective targeting and modulation of distinct cell types and neuron subtypes is central to
understanding complex neural circuitry and could enable electronic treatments that target …

The emergence of a polybasic cleavage motif for the protease furin in SARS-CoV-2 spike
has been established as a major factor for human viral transmission. The region N-terminal …

Cell type-specific interfaces within living animals will be invaluable for achieving
communication with identifiable cells over the long term, enabling applications across many …

Aberrant hypoxic stress will initiate a cascade of pathological consequence observed
prominently in tumorigenesis. Understanding of hypoxia's role in tumorigenesis is highly …

Exo-enzymatic glyco-engineering of cell-surface glycoconjugates enables the selective
display of well-defined glyco-motifs bearing bioorthogonal functional groups, which can be …