The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …

Various internal and external factors negatively affect the homeostatic equilibrium of
organisms at the molecular to the whole-body level, inducing the so-called state of stress …

A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty
in older persons, but the molecular mechanisms of such decline are not understood. Here …

The endoplasmic reticulum (ER) plays a vital function in maintaining cellular homeostasis.
Endoplasmic reticulum stress (ERS) can trigger various modes of cell death by activating the …

Previously, we reported that elevated serum levels of heat shock protein 27 (HSP27) are
predictive of a lower risk of having a heart attack, stroke, or death from cardiovascular …

Within the last two decades, there has been increasing evidence that heat-shock proteins
can have a differential influence on the immune system. They can either provoke or …

Amyotrophic lateral sclerosis (ALS) and spinal and bulbar muscular atrophy (SBMA) are two
motoneuron diseases (MNDs) characterized by aberrant protein behavior in affected cells. In …

A real-time, noninvasive, and clinically applicable aging test in humans has yet to be
established. Herein we propose a sweat-and wearable-based test to determine biological …

Aging is a prominent risk factor for neurodegenerative disease. Defining gene expression
mechanisms affecting healthy brain aging should lead to insight into genes that modulate …

This study analyzed the effect of gender on the abundances of 20 protein biomarkers of
tenderness and/or intramuscular fat content in five muscles: Longissimus thoracis …