The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …

Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as
promising candidate targets for cancer treatment. These proteins complexed with cyclins …

A challenge in oncology is to rationally and effectively integrate immunotherapy with
traditional modalities, including radiotherapy. Here, we demonstrate that radiotherapy …

Accurate monitoring the surrounding environment is an important research direction in the
field of unmanned systems such as bio-robotics, and has attracted much research attention …

Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …

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The inability to repair DNA damage properly in mammals leads to various disorders and
enhanced rates of tumour development. Organisms respond to chromosomal insults by …

The majority of human cancers acquire mutations that abrogate the p53 tumor suppressor
network and, as a consequence, p53 is one of the most extensively studied proteins in …

Pancreatic cancer is a lethal disease with limited opportunity for resectable surgery as the
first choice for cure due to its late diagnosis and early metastasis. The desmoplastic stroma …

Chk1, an evolutionarily conserved protein kinase, has been implicated in cell cycle
checkpoint control in lower eukaryotes. By gene disruption, we show that CHK1 deficiency …