Parkinson's disease (PD) is a complex, multi-system neurodegenerative disorder. The
second most common neurodegenerative disorder after Alzheimer's disease, it affects …

Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …

Bradykinesia is one of the cardinal motor symptoms of Parkinson's disease and other
parkinsonisms. The various clinical aspects related to bradykinesia and the …

Synchronised neuronal oscillations at beta frequencies are prevalent in the human motor
system, but their function is unclear. In this Opinion article, we propose that the levels of beta …

Deep brain stimulation (DBS) has become the treatment of choice for advanced stages of
Parkinson's disease, medically intractable essential tremor, and complicated segmental and …

Parkinson's disease is a common and disabling disorder of movement owing to
dopaminergic denervation of the striatum. However, it is still unclear how this denervation …

The huge number of neurons in the human brain are connected to form functionally
specialized assemblies. The brain's amazing processing capabilities rest on local …

Parkinson's disease (PD) is associated with exaggerated oscillatory synchrony in the basal
ganglia at frequencies over 8–35 Hz. Studies have demonstrated a suppression of local field …

The motor signs of Parkinson's disease are thought to result in large part from a reduction of
the level of dopamine in the basal ganglia. Over the last few years, many of the functional …

In patients with Parkinson's disease and in animal models of this disorder, neurons in the
basal ganglia and related regions in thalamus and cortex show changes that can be …