The flavivirus NS2B–NS3 protease–helicase as a target for antiviral drug development
The flavivirus NS3 protein is associated with the endoplasmic reticulum membrane via its
close interaction with the central hydrophilic region of the NS2B integral membrane protein …
close interaction with the central hydrophilic region of the NS2B integral membrane protein …
Current trends and limitations in dengue antiviral research
JO Obi, H Gutiérrez-Barbosa, JV Chua… - Tropical Medicine and …, 2021 - mdpi.com
Dengue is the most prevalent arthropod-borne viral disease worldwide and affects
approximately 2.5 billion people living in over 100 countries. Increasing geographic …
approximately 2.5 billion people living in over 100 countries. Increasing geographic …
Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug
E Mastrangelo, M Pezzullo… - Journal of …, 2012 - academic.oup.com
Objectives Infection with yellow fever virus (YFV), the prototypic mosquito-borne flavivirus,
causes severe febrile disease with haemorrhage, multi-organ failure and a high mortality …
causes severe febrile disease with haemorrhage, multi-organ failure and a high mortality …
Ten years of dengue drug discovery: progress and prospects
To combat neglected diseases, the Novartis Institute of Tropical Diseases (NITD) was
founded in 2002 through private–public funding from Novartis and the Singapore Economic …
founded in 2002 through private–public funding from Novartis and the Singapore Economic …
[HTML][HTML] West Nile virus epizootic in Germany, 2018
The summer of 2018 in Germany was the second hottest and driest on record. These
generally extremely favorable climatic conditions most likely triggered the further expansion …
generally extremely favorable climatic conditions most likely triggered the further expansion …
In Vitro Reconstitution of SARS-Coronavirus mRNA Cap Methylation
M Bouvet, C Debarnot, I Imbert, B Selisko… - PLoS …, 2010 - journals.plos.org
SARS-coronavirus (SARS-CoV) genome expression depends on the synthesis of a set of
mRNAs, which presumably are capped at their 5′ end and direct the synthesis of all viral …
mRNAs, which presumably are capped at their 5′ end and direct the synthesis of all viral …
Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2′-O-methyltransferase nsp10/nsp16 complex
Cellular and viral S-adenosylmethionine-dependent methyltransferases are involved in
many regulated processes such as metabolism, detoxification, signal transduction …
many regulated processes such as metabolism, detoxification, signal transduction …
Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus
The successive emergence of highly pathogenic coronaviruses (CoVs) such as the Severe
Acute Respiratory Syndrome (SARS-CoV) in 2003 and the Middle East Respiratory …
Acute Respiratory Syndrome (SARS-CoV) in 2003 and the Middle East Respiratory …
The dengue virus NS5 protein as a target for drug discovery
The non-structural protein 5 (NS5) of flaviviruses is the most conserved amongst the viral
proteins. It is about 900 kDa and bears enzymatic activities that play vital roles in virus …
proteins. It is about 900 kDa and bears enzymatic activities that play vital roles in virus …
A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication
Flavivirus RNA replication occurs within a replication complex (RC) that assembles on ER
membranes and comprises both non-structural (NS) viral proteins and host cofactors. As the …
membranes and comprises both non-structural (NS) viral proteins and host cofactors. As the …