The development of culture-independent techniques for microbiological analysis has
uncovered the previously unappreciated complexity of the bacterial microbiome at various …

Impulse oscillometry (IOS) is a variant of forced oscillation technique, described by Dubois
over 50 years ago, which permits passive measurement of lung mechanics. In this method …

Measuring lung function is an important component in the decision making process for
patients with obstructive airways disease (OAD). Not only does it help in arriving at a specific …

Objective: This study sought to characterize the epidemiologic, clinical, humanistic, and
economic burden of patients with asthma uncontrolled by GINA Steps 4 or 5 treatment …

Rationale: Asthma is characterized by disease within the small airways. Several studies
have suggested that forced oscillation technique–derived resistance at 5 Hz (R5) …

Normal human breathing exhibits complex variability in both respiratory rhythm and volume.
Analyzing such nonlinear fluctuations may provide clinically relevant information in patients …

Background The role of small airway obstruction in the clinical expression of asthma is
incompletely understood. Objective We tested the hypotheses that markers of small airway …

Respiratory diseases are highly complex, being driven by host–environment interactions
and manifested by inflammatory, structural, and functional abnormalities that vary over time …

Background Classic spirometry is effort dependent and of limited value in assessing small
airways. Peripheral airway involvement, and relation to poor control, in asthma, has been …

Background Congenital diaphragmatic hernia (CDH) is associated with significant
pulmonary morbidity. Previous investigation has shown that postnatal inpatient morbidity is …