The α7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

Rationale and objective Auditory sensory gating, a biological measurement of the ability to
suppress the evoked response to the second of two auditory stimuli, is diminished in people …

Nicotine stimulates the dopamine (DA) system, which is essential for its rewarding effect.
Nicotine is also aversive at high doses; yet, our knowledge about nicotine's dose-dependent …

The tryptophan metabolite kynurenic acid (KYNA) has long been recognized as an NMDA
receptor antagonist. Here, interactions between KYNA and the nicotinic system in the brain …

Despite recent advances in understanding the causes of epilepsy, especially the genetic,
comprehending the biological mechanisms that lead to the epileptic phenotype remains …

This review summarizes studies that attempted to determine the subtypes of nicotinic
acetylcholine receptors (nAChR) expressed in the dopaminergic nerve terminals in the …

Abstract SSR180711 (4-bromophenyl 1, 4diazabicyclo (3.2. 2) nonane-4-carboxylate,
monohydrochloride) is a selective α7 nicotinic receptor (n-AChR) partial agonist. Based on …

It has been suggested that neuronal hyperexcitability contributes to Alzheimer's disease
(AD), so we asked how hyperexcitability develops in a common mouse model of β-amyloid …

In humans, nicotine has been shown to improve attention in both normal and impaired
individuals. Observations in rats reflect some, but not all aspects of the nicotine-induced …

Rationale Tobacco use is implicated in approximately 440,000 deaths per year, making it
the leading cause of preventable death in the United States. Although it is generally …