Primary structure of glycans by NMR spectroscopy
C Fontana, G Widmalm - Chemical Reviews, 2023 - ACS Publications
Glycans, carbohydrate molecules in the realm of biology, are present as biomedically
important glycoconjugates and a characteristic aspect is that their structures in many …
important glycoconjugates and a characteristic aspect is that their structures in many …
[HTML][HTML] Affinity measurement of strong ligands with NMR spectroscopy: Limitations and ways to overcome them
C Dalvit, I Gmür, P Rößler, AD Gossert - Progress in Nuclear Magnetic …, 2023 - Elsevier
NMR spectroscopy is currently extensively used in binding assays for hit identification, but its
use in dissociation constant determination is more limited when compared to other …
use in dissociation constant determination is more limited when compared to other …
Overhauser enhanced liquid state nuclear magnetic resonance spectroscopy in one and two dimensions
Nuclear magnetic resonance (NMR) is fundamental in the natural sciences, from chemical
analysis and structural biology, to medicine and physics. Despite its enormous …
analysis and structural biology, to medicine and physics. Despite its enormous …
SHARPER-DOSY: Sensitivity enhanced diffusion-ordered NMR spectroscopy
G Peat, PJ Boaler, CL Dickson, GC Lloyd-Jones… - Nature …, 2023 - nature.com
Since its discovery in mid-20th century, the sensitivity of Nuclear Magnetic Resonance
(NMR) has increased steadily, in part due to the design of new, sophisticated NMR …
(NMR) has increased steadily, in part due to the design of new, sophisticated NMR …
Multinuclear 1D and 2D NMR with 19F-Photo-CIDNP hyperpolarization in a microfluidic chip with untuned microcoil
Abstract Nuclear Magnetic Resonance (NMR) spectroscopy is a most powerful molecular
characterization and quantification technique, yet two major persistent factors limit its more …
characterization and quantification technique, yet two major persistent factors limit its more …
Frémy's salt as a low-persistence hyperpolarization agent: efficient dynamic nuclear polarization plus rapid radical scavenging
Nuclear magnetic resonance (NMR) spectroscopy is a key technique for molecular structure
determination in solution. However, due to its low sensitivity, many efforts have been made …
determination in solution. However, due to its low sensitivity, many efforts have been made …
Toward protein NMR at physiological concentrations by hyperpolarized water—Finding and mapping uncharted conformational spaces
Nuclear magnetic resonance (NMR) spectroscopy is a key method for determining the
structural dynamics of proteins in their native solution state. However, the low sensitivity of …
structural dynamics of proteins in their native solution state. However, the low sensitivity of …
Live magnetic observation of parahydrogen hyperpolarization dynamics
Hyperpolarized nuclear spins in molecules exhibit high magnetization that is unachievable
by classical polarization techniques, making them widely used as sensors in physics …
by classical polarization techniques, making them widely used as sensors in physics …
Parahydrogen in Reversible Exchange Induces Long-Lived 15N Hyperpolarization of Anticancer Drugs Anastrozole and Letrozole
K MacCulloch, A Browning, P TomHon… - Analytical …, 2023 - ACS Publications
Hyperpolarization modalities overcome the sensitivity limitations of NMR and unlock new
applications. Signal amplification by reversible exchange (SABRE) is a particularly cheap …
applications. Signal amplification by reversible exchange (SABRE) is a particularly cheap …
Cross-Polarization of Insensitive Nuclei from Water Protons for Detection of Protein–Ligand Binding
Hyperpolarization derived from water protons enhances the NMR signal of 15N nuclei in a
small molecule, enabling the sensitive detection of a protein–ligand interaction. The water …
small molecule, enabling the sensitive detection of a protein–ligand interaction. The water …