[HTML][HTML] Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing

S Patel, S Srivastava, MR Singh, D Singh - Biomedicine & …, 2019 - Elsevier
Wound management in diabetic patient is of an extreme clinical and social concern. The
delayed and impaired healing makes it more critical for research focus. The research on …

Polymer–drug conjugate therapeutics: advances, insights and prospects

I Ekladious, YL Colson, MW Grinstaff - Nature reviews Drug discovery, 2019 - nature.com
Polymer–drug conjugates have long been a mainstay of the drug delivery field, with several
conjugates successfully translated into clinical practice. The conjugation of therapeutic …

Therapeutic strategies for enhancing angiogenesis in wound healing

AP Veith, K Henderson, A Spencer, AD Sligar… - Advanced drug delivery …, 2019 - Elsevier
The enhancement of wound healing has been a goal of medical practitioners for thousands
of years. The development of chronic, non-healing wounds is a persistent medical problem …

Novel electrospun chitosan/polyvinyl alcohol/zinc oxide nanofibrous mats with antibacterial and antioxidant properties for diabetic wound healing

R Ahmed, M Tariq, I Ali, R Asghar, PN Khanam… - International journal of …, 2018 - Elsevier
Non-healing wound is a serious complication of diabetes, associated with extremely slow
wound closure, and a high rate of infection, resulting in amputation or losses of limbs, high …

Therapeutic protein–polymer conjugates: advancing beyond PEGylation

EM Pelegri-O'Day, EW Lin… - Journal of the American …, 2014 - ACS Publications
Protein–polymer conjugates are widely used as therapeutics. All Food and Drug
Administration (FDA)-approved protein conjugates are covalently linked to poly (ethylene …

A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing

CY Gong, QJ Wu, YJ Wang, DD Zhang, F Luo, X Zhao… - Biomaterials, 2013 - Elsevier
A biodegradable in situ gel-forming controlled drug delivery system composed of curcumin
loaded micelles and thermosensitive hydrogel was prepared and applied for cutaneous …

Anti-inflammation biomaterial platforms for chronic wound healing

Z Xu, B Liang, J Tian, J Wu - Biomaterials science, 2021 - pubs.rsc.org
Nowadays, there has been an increase in the number of people with chronic wounds, which
has resulted in serious health problems worldwide. The rate-limiting stage of chronic wound …

Potential applications of advanced nano/hydrogels in biomedicine: static, dynamic, multi‐stage, and bioinspired

MH Ayoubi‐Joshaghani, K Seidi, M Azizi… - Advanced Functional …, 2020 - Wiley Online Library
Novel advanced hydrogels can provide a versatile platform for controlled delivery and
release of various cargos, with a myriad of biomedical applications. These gel‐based …

Constructing a cell microenvironment with biomaterial scaffolds for stem cell therapy

X Zhao, Q Li, Z Guo, Z Li - Stem cell research & therapy, 2021 - Springer
Stem cell therapy is widely recognized as a promising strategy for exerting therapeutic
effects after injury in degenerative diseases. However, limitations such as low cell retention …

Mesenchymal stem cell-laden anti-inflammatory hydrogel enhances diabetic wound healing

S Chen, J Shi, M Zhang, Y Chen, X Wang, L Zhang… - Scientific reports, 2015 - nature.com
The purpose of this study was to permit bone marrow mesenchymal stem cells (BMSCs) to
reach their full potential in the treatment of chronic wounds. A biocompatible multifunctional …