The dynamic regulation of chromatin accessibility is one of the prominent characteristics of
eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which …

Abstract The Human Genome Project marked a major milestone in the scientific community
as it unravelled the~ 3 billion bases that are central to crucial aspects of human life. Despite …

Rationale: Cardiac pacemaker cells (PCs) in the sinoatrial node (SAN) have a distinct gene
expression program that allows them to fire automatically and initiate the heartbeat …

Rationale: Dextro-transposition of the great arteries (D-TGA) is a severe congenital heart
defect which affects approximately 1 in 4,000 live births. While there are several reports of D …

The sinoatrial node (SAN) is the primary pacemaker of the mammalian heart, initiating its
electrical activation and ensuring that the heart's functional cardiac output meets …

Background: The sinoatrial node (SAN) functions as the pacemaker of the heart, initiating
rhythmic heartbeats. Despite its importance, the SAN is one of the most poorly understood …

While 3D chromatin organization in topologically associating domains (TADs) and loops
mediating regulatory element-promoter interactions is crucial for tissue-specific gene …

The mammalian cardiac conduction system (CCS) is a multifaceted continuum of electrically
distinct, interconnected constructs within the myocardial mass. The key components are the …

Development of the heart is a very intricate and multiplex process as it involves not only the
three spatial dimensions but also the fourth or time dimension. Over time, the heart of an …

Heart rhythm disturbances caused by different etiologies may affect pediatric and adult
patients with life-threatening consequences. When pharmacological therapy is ineffective in …