Developing recombinant antibodies by phage display against infectious diseases and toxins for diagnostics and therapy

KDR Roth, EV Wenzel, M Ruschig, S Steinke… - Frontiers in cellular …, 2021 - frontiersin.org
Antibodies are essential molecules for diagnosis and treatment of diseases caused by
pathogens and their toxins. Antibodies were integrated in our medical repertoire against …

Phage display antibody libraries: A robust approach for generation of recombinant human monoclonal antibodies

R Kumar, HA Parray, T Shrivastava, S Sinha… - International journal of …, 2019 - Elsevier
Monoclonal antibodies (mAbs) and their derivatives have achieved remarkable success as
medicine, targeting both diagnostic and therapeutic applications associated with …

Designing human antibodies by phage display

A Frenzel, J Kügler, S Helmsing, D Meier… - Transfusion Medicine …, 2017 - karger.com
With six approved products and more than 60 candidates in clinical testing, human
monoclonal antibody discovery by phage display is well established as a robust and reliable …

SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface

F Bertoglio, D Meier, N Langreder, S Steinke… - Nature …, 2021 - nature.com
COVID-19 is a severe acute respiratory disease caused by SARS-CoV-2, a new recently
emerged sarbecovirus. This virus uses the human ACE2 enzyme as receptor for cell entry …

The marburgvirus-neutralizing human monoclonal antibody MR191 targets a conserved site to block virus receptor binding

LB King, ML Fusco, AI Flyak, PA Ilinykh, K Huang… - Cell host & …, 2018 - cell.com
Since their first identification 50 years ago, marburgviruses have emerged several times,
with 83%–90% lethality in the largest outbreaks. Although no vaccines or therapeutics are …

How can monoclonal antibodies be harnessed against neglected tropical diseases and other infectious diseases?

AH Laustsen - Expert opinion on drug discovery, 2019 - Taylor & Francis
Introduction: Monoclonal antibody-based therapies now represent the single-largest class of
molecules undergoing clinical investigation. Although a handful of different monoclonal …

Infectious disease antibodies for biomedical applications: A mini review of immune antibody phage library repertoire

JY Lai, TS Lim - International Journal of Biological Macromolecules, 2020 - Elsevier
Antibody phage display is regarded as a critical tool for the development of monoclonal
antibodies for infectious diseases. The different classes of antibody libraries are classified …

Antibody phage display technology for sensor-based virus detection: Current status and future prospects

OI Guliy, SS Evstigneeva, VA Khanadeev, LA Dykman - Biosensors, 2023 - mdpi.com
Viruses are widespread in the environment, and many of them are major pathogens of
serious plant, animal, and human diseases. The risk of pathogenicity, together with the …

Antibodies against anthrax toxins: A long way from Benchlab to the bedside

A Avril, JN Tournier, JC Paucod, B Fournes, P Thullier… - Toxins, 2022 - mdpi.com
Anthrax is an acute disease caused by the bacterium Bacillus anthracis, and is a potential
biowarfare/bioterrorist agent. Its pulmonary form, caused by inhalation of the spores, is …

Antibody selection in solution using magnetic beads

PA Heine, M Ruschig, N Langreder, EV Wenzel… - Phage Display: Methods …, 2023 - Springer
Antibody phage display is a valuable in vitro technology to generate recombinant, sequence-
defined antibodies for research, diagnostics, and therapy. Up to now (autumn 2022), 14 …