All implanted biomaterials are targets of the host's immune system. While the host
inflammatory response was once considered a detrimental force to be blunted or avoided, in …

Inflammatory monocytes and tissue-resident macrophages are key regulators of tissue
repair, regeneration, and fibrosis. After tissue injury, monocytes and macrophages undergo …

Current therapeutic strategies such as angiogenic therapy and anti-inflammatory therapy for
treating myocardial infarction have limited success. An effective approach may benefit from …

Acute inflammation is essential for initiating and coordinating the body's response to injuries
and infections. However, in acute inflammatory diseases, inflammation is not resolved but …

As a greater proportion of patients survive their initial cardiac insult, medical systems
worldwide are being faced with an ever-growing need to understand the mechanisms …

Aims Acute myocardial infarction (MI) is the leading cause of mortality worldwide. Anti-
inflammatory strategies to reduce neutrophil-driven acute post-MI injury have been shown to …

Macrophages regulate tissue regeneration following injury. They can worsen tissue injury by
producing reactive oxygen species and other toxic mediators that disrupt cell metabolism …

Macrophages play critical roles in homeostatic maintenance of the myocardium under
normal conditions and in tissue repair after injury. In the steady-state heart, resident cardiac …

The prompt removal of apoptotic cells by phagocytes is important for maintaining tissue
homeostasis. The molecular and cellular events that underpin apoptotic cell recognition and …

Extracellular vesicles (EVs)—particularly exosomes and microvesicles (MVs)—are attracting
considerable interest in the cardiovascular field as the wide range of their functions is …