Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …

Regulation of gene expression is achieved by sequence-specific transcriptional regulators,
which convey the information that is contained in the sequence of DNA into RNA …

Glioblastomas are universally fatal cancers and contain self-renewing glioblastoma stem
cells (GSCs) that initiate tumors. Traditional anticancer drug discovery based on in vitro …

In mammalian cells, the SET1/MLL complexes are the main writers of the H3K4 methyl mark
that is associated with active gene expression. The activities of these complexes are …

Abstract Histone H3 Lys4 (H3K4) methylation is catalyzed by the Histone–Lysine N-
Methyltransferase 2 (KMT2) protein family, and its members are required for gene …

KMT2 (histone-lysine N-methyltransferase subclass 2) complexes methylate lysine 4 on the
histone H3 tail at gene promoters and gene enhancers and, thus, control the process of …

Abstract Rationale: Approximately 30-40% of estrogen receptor (ER)-positive breast cancer
(BC) cases recur after tamoxifen therapy. Thus, additional studies on the mechanisms …

DPY30, a core subunit of the SET1/MLL histone H3K4 methyltransferase complexes, plays
an important role in diverse biological functions through the epigenetic regulation of gene …

Background We have previously described the existence of two phenotypically distinct cell
subsets in ALK-positive anaplastic large cell lymphoma (ALK+ ALCL) based on their …

Chidamide is the first oral subtype-selective histone deacetylase inhibitor (HDACI) approved
in China as well as the first HDACI of the benzamide class approved for the treatment of …