Noscapine is a benzylisoquinoline alkaloid isolated from poppy extract, used as an
antitussive since the 1950s, and has no addictive or euphoric effects. Various studies have …

Microtubules form crucial dynamic structural cellular components of the cell and are
composed of the alpha beta tubulin heterodimers. Microtubules are involved in a wide …

Tubulin, an important target in tumor therapy, is one of the hotspots in the field of
antineoplastic drugs in recent years, and it is of great significance to design and screen new …

The major cause of death in cancer patients is strongly associated with metastasis. While
much remains to be understood, microtubule-associated proteins (MAPs) have shed light on …

Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs)
are proteins and protein segments that usually do not acquire well-defined folded structures …

We present a new class of derivatives of noscapine, 1, 3-diynyl-noscapinoids of an
antitussive plant alkaloid, noscapine based on our in silico efforts that binds tubulin and …

Noscapine is a natural product first isolated from the opium poppy (Papaver somniferum L.)
with anticancer properties. In this work, we report the synthesis and cellular screening of a …

Abstract We developed 1, 3-diynyl derivatives of noscapine (an opium alkaloid) through in
silico combinatorial approach and screened out a panel of promising derivatives that bind …

Beta-sitosterol (β-SITO), a phytosterol present in many edible vegetables, has been reported
to possess antineoplastic properties and cancer treatment potential. We have shown …

Aim To rationally-design, synthesize, characterize, biologically evaluate, and to elucidate the
anticancer mechanism of action of a novel analogue of noscapine, N-propargyl noscapine …