Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Histone side chains are post-translationally modified at multiple sites, including at Lys36 on
histone H3 (H3K36). Several enzymes from yeast and humans, including the …

Interferon-α (IFNα) signaling is essential for antiviral response via induction of IFN-
stimulated genes (ISGs). Through a non-biased high-throughput RNAi screening of 711 …

Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of
genetic information from DNA to proteins by expanding the coding capacity of genomes …

H3K27 methylation mediated by the histone methyltransferase complex PRC2 is critical for
transcriptional regulation, Polycomb silencing, Drosophila segmentation, mammalian X …

Posttranslational modifications (PTMs) of tubulin specify microtubules for specialized cellular
functions and comprise what is termed a" tubulin code." PTMs of histones comprise an …

Accurate reconstruction of the regulatory networks that control gene expression is one of the
key current challenges in molecular biology. Although gene expression and chromatin state …

Erasure and subsequent reinstatement of DNA methylation in the germline, especially at
imprinted CpG islands (CGIs), is crucial to embryogenesis in mammals. The mechanisms …

The genomes of higher organisms are packaged in nucleosomes with functional histone
modifications. Until now, genome-wide nucleosome and histone modification studies have …

The NSD (nuclear receptor SET domain-containing) family of histone lysine
methyltransferases is a critical participant in chromatin integrity as evidenced by the number …