Cells are equipped with numerous sensors that recognize nucleic acids, which probably
evolved for defence against viruses. Once triggered, these sensors stimulate the production …

The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …

In addition to constituting the genetic material of an organism, DNA is a tracer for the
recognition of foreign pathogens and a trigger of the innate immune system. cGAS functions …

Bacteria have evolved diverse immunity mechanisms to protect themselves against the
constant onslaught of bacteriophages,–. Similar to how eukaryotic innate immune systems …

The cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS) senses
invasion of pathogenic DNA and stimulates inflammatory signaling, autophagy, and …

SARS-CoV-2 is the cause of a pandemic with growing global mortality. Using
comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) …

Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the
structural similarity between those and host nucleic acids, mammalian cells have been able …

A system for programmable export of RNA molecules from living cells would enable both
non-destructive monitoring of cell dynamics and engineering of cells capable of delivering …

cGAS is an intracellular innate immune sensor that detects double-stranded DNA. The
presence of billions of base pairs of genomic DNA in all nucleated cells raises the question …

Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was
identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the …