Methionine cycle in nonalcoholic fatty liver disease and its potential applications

H Wang, Y Wu, W Tang - Biochemical Pharmacology, 2022 - Elsevier
As a chronic metabolic disease affecting epidemic proportions worldwide, the pathogenesis
of Nonalcoholic Fatty Liver Disease (NAFLD) is not clear yet. There is also a lack of precise …

Hyperhomocysteinemia impairs regional blood flow: involvements of endothelial and neuronal nitric oxide

N Toda, T Okamura - Pflügers Archiv-European Journal of Physiology, 2016 - Springer
Increasing evidence support the idea that hyperhomocysteinemia (HHcy) is responsible for
pathogenesis underlying cerebral, coronary, renal, and other vascular circulatory disorders …

GABA transporter sustains IL-1β production in macrophages

Y Xia, F He, X Wu, B Tan, S Chen, Y Liao, M Qi… - Science …, 2021 - science.org
Accumulating evidence shows that nervous system governs host immune responses;
however, how γ-aminobutyric acid (GABA) ergic system shapes the function of innate …

Avascular necrosis of femoral head: a metabolomic, biophysical, biochemical, electron microscopic and histopathological characterization

A Narayanan, P Khanchandani, RM Borkar… - Scientific reports, 2017 - nature.com
Avascular necrosis of the femur head (AVNFH) is a debilitating disease caused due to the
use of alcohol, steroids, following trauma or unclear (idiopathic) etiology, affecting mostly the …

Vitamin B12 and chronic kidney disease

HHL Wu, AYM Wang - Vitamins and hormones, 2022 - Elsevier
Abstract Chronic Kidney Disease (CKD) is an emerging public health issue with a fast-
growing global prevalence. Impairment in vitamin B12 metabolism is considered a …

Nitrous oxide abuse in the emergency practice, and Review of toxicity mechanisms and potential markers

MJ Chevalier-Curt, G Grzych, C Tard, J Lannoy… - Food and Chemical …, 2022 - Elsevier
Nitrous oxide (N 2 O) toxicity is a concern common to several medical fields. Here,
retrospective study of four N 2 O abuses with neurological signs in the emergency practice …

Homocysteine impairs porcine oocyte quality via deregulation of one-carbon metabolism and hypermethylation of mitochondrial DNA

L Jia, Y Zeng, Y Hu, J Liu, C Yin, Y Niu… - Biology of …, 2019 - academic.oup.com
Homocysteine (Hcy) is an intermediate in the one-carbon metabolism that donates methyl
groups for methylation processes involved in epigenetic gene regulation. Although poor …

SARS-CoV-2 infection: what is currently known about homocysteine involvement?

N Filip, E Cojocaru, OV Badulescu, A Clim, AC Pinzariu… - Diagnostics, 2022 - mdpi.com
Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
spread rapidly throughout the world causing health, social and economic instability. The …

Polymorphisms of methalenetetrahydrofolate reductase in recurrent pregnancy loss: an overview of systematic reviews and meta-analyses

B Du, X Shi, C Yin, X Feng - Journal of assisted reproduction and genetics, 2019 - Springer
Purpose The aim is to summarize and evaluate current systematic reviews and meta-
analyses on MTHFR polymorphisms in recurrent pregnancy loss (RPL). Methods We …

Homocysteine as a predictive biomarker in early diagnosis of renal failure susceptibility and prognostic diagnosis for end stages renal disease

HK Amin, MIK El-Sayed, OF Leheta - Renal failure, 2016 - Taylor & Francis
Glomerular filtration rate and/or creatinine are not accurate methods for renal failure
prediction. This study tested homocysteine (Hcy) as a predictive and prognostic marker for …