The study examines the influence of three types of hypercaloric diets on metabolic
parameters, inflammatory markers, and oxidative stress in experimental model. Male Wistar …

The endogenous antioxidant defense plays a big part in the pathogenesis of non-alcoholic
fatty liver disease (NAFLD), a common metabolic disorder that can lead to serious …

Abstract α-Ketoglutarate (AKG), a crucial intermediate in the tricarboxylic acid cycle, has
been demonstrated to mitigate hyperlipidemia-induced dyslipidemia and endothelial …

Consumption of high-calorie diets leads to excessive accumulation of storage lipids in
adipose tissue. Metabolic changes occur not only in adipose tissue but in other tissues, too …

Background High caloric diets with high amounts of fats and sweeteners such as fructose
may predispose organisms to neurodegenerative diseases. Methods This study aimed to …

Studies on antiaging remedies in insect models sometimes show discrepancies in results.
These discrepancies could be explained by different responses of short‐and long‐lived …

α-酮戊二酸(alpha-ketoglutarate, α-KG) 是三羧酸循环的内源性中间代谢产物,
参与多种细胞代谢途径, 作为能量供体, 氨基酸前体, 表观遗传调控因子发挥作用. α-KG …

Obesity and metabolic syndrome are becoming the number one health problem in modern
society. Unhealthy diet with sedentary life style are considered to be the main causes of …

Obesity and its metabolic complications are global health concerns with rising prevalence
worldwide. These conditions are influenced not only by biological and lifestyle factors but …

Metabolic syndrome (MetS) consists in a cluster of metabolic complications, characterized
by the simultaneous prevalence of at least three of the following medical conditions: central …