Despite substantial efforts dedicated to the development of new, nonaddictive analgesics,
success in treating pain has been limited. Clinically available analgesic agents generally …

Simple Summary Medical control of cancer pain is often unsatisfactory. Narcotic drugs
(opioids) are effective pain killers, but they have important negative effects on the central …

CDKL5 is a brain-enriched serine/threonine kinase, associated with a profound
developmental and epileptic encephalopathy called CDKL5 deficiency disorder (CDD). To …

Developmental and epileptic encephalopathies (DEEs) are a group of rare childhood
disorders characterized by severe epilepsy and cognitive deficits. Numerous DEE genes …

Gazami crab (Portunus trituberculatus) is prone to spoilage during storage and
transportation. More research is needed to determine how to reliably show its freshness and …

Mouse models have made innumerable contributions to understanding the genetic basis of
neurological disease and pathogenic mechanisms and to therapy development. Here we …

Persistent pain is sustained by maladaptive changes in gene transcription resulting in
altered function of the relevant circuits; therapies are still unsatisfactory. The epigenetic …

Pediatric genetic epilepsies, such as CDKL5 Deficiency Disorder (CDD), are severely
debilitating, with early-onset seizures occurring more than ten times daily in extreme cases …

Chronic pain associated with osteoarthritis (OA) remains an intractable problem with few
effective treatment options. New approaches are needed to model the disease biology and …

Hemiplegic cerebral palsy (HCP) is a non-progressive movement and posture disorder that
affects one side of the body. Constraint-induced movement therapy (CIMT) can improve the …