Lipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their
applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech …

Extracellular vesicles (EVs) are vesicles with a lipid bilayer membrane on the outside, which
are widely found in various body fluids and contain biological macromolecules such as …

We have demonstrated, for the first time that microvesicles, a sub-type of extracellular
vesicles (EVs) derived from hCMEC/D3: a human brain endothelial cell (BEC) line transfer …

A variety of neuroprotectants have shown promise in treating ischemic stroke, yet their
delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier …

Simple Summary Exosomal communication in the tumor microenvironment plays a crucial
role in cancer development, progression, and metastasis, and is achieved by either short …

In designing a new drug, considering the preferred route of administration, various
requirements must be fulfilled. Active molecules pharmacokinetics should be reliable with a …

The field of drug delivery has made tremendous advances in increasing the therapeutic
potential of a variety of drug candidates spanning from small molecules to large molecular …

Ischemic stroke causes brain endothelial cell (BEC) death and damages tight junction
integrity of the blood-brain barrier (BBB). We harnessed the innate mitochondrial load of …

Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in
mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed …

Simple Summary Cancer metastasis accounts for almost 90% of cancer deaths worldwide.
The efficiency of current surgical, radiotherapeutic, and chemotherapeutic approaches is …