Mechanoregulation of YAP and TAZ in cellular homeostasis and disease progression
Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …
homeostasis. During organ development and tissue injury repair, compressive and tensional …
The Warburg effect 97 years after its discovery
RM Pascale, DF Calvisi, MM Simile, CF Feo, F Feo - Cancers, 2020 - mdpi.com
Simple Summary The deregulation of the oxidative metabolism in cancer cells,
characterized by an increased ratio between glycolysis and oxygen consumption (Warburgv …
characterized by an increased ratio between glycolysis and oxygen consumption (Warburgv …
[HTML][HTML] Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease characterized by airway
remodeling, inflammation, alveolar destruction, and fibrosis. We utilized single-cell RNA …
remodeling, inflammation, alveolar destruction, and fibrosis. We utilized single-cell RNA …
[HTML][HTML] Tumor-stroma mechanics coordinate amino acid availability to sustain tumor growth and malignancy
Dysregulation of extracellular matrix (ECM) deposition and cellular metabolism promotes
tumor aggressiveness by sustaining the activity of key growth, invasion, and survival …
tumor aggressiveness by sustaining the activity of key growth, invasion, and survival …
Hepatocyte TAZ/WWTR1 promotes inflammation and fibrosis in nonalcoholic steatohepatitis
Nonalcoholic steatohepatitis (NASH) is a leading cause of liver disease worldwide.
However, the molecular basis of how benign steatosis progresses to NASH is incompletely …
However, the molecular basis of how benign steatosis progresses to NASH is incompletely …
Pathophysiology of reversible cerebral vasoconstriction syndrome
Reversible cerebral vasoconstriction syndrome (RCVS) is a complex neurovascular disorder
being recognized during the past two decades. It is characterized by multiple abrupt severe …
being recognized during the past two decades. It is characterized by multiple abrupt severe …
Role of extracellular matrix in the pathogenesis of pulmonary arterial hypertension
T Thenappan, SY Chan… - American Journal of …, 2018 - journals.physiology.org
Pulmonary arterial hypertension (PAH) is characterized by remodeling of the extracellular
matrix (ECM) of the pulmonary arteries with increased collagen deposition, cross-linkage of …
matrix (ECM) of the pulmonary arteries with increased collagen deposition, cross-linkage of …
Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis
Tissue fibrosis is characterized by uncontrolled deposition and diminished clearance of
fibrous connective tissue proteins, ultimately leading to organ scarring. Yes-associated …
fibrous connective tissue proteins, ultimately leading to organ scarring. Yes-associated …
Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice
S Alsamman, SA Christenson, A Yu… - Science translational …, 2020 - science.org
Hepatic stellate cells (HSCs) drive hepatic fibrosis. Therapies that inactivate HSCs have
clinical potential as antifibrotic agents. We previously identified acid ceramidase (aCDase) …
clinical potential as antifibrotic agents. We previously identified acid ceramidase (aCDase) …
YAP/TAZ activation as a target for treating metastatic cancer
Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ)
have both emerged as important drivers of cancer progression and metastasis. YAP and …
have both emerged as important drivers of cancer progression and metastasis. YAP and …