Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: integration of the glutamate/GABA-glutamine cycle

JV Andersen, A Schousboe, A Verkhratsky - Progress in neurobiology, 2022 - Elsevier
Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

Astrocytes as key regulators of brain energy metabolism: new therapeutic perspectives

E Beard, S Lengacher, S Dias, PJ Magistretti… - Frontiers in …, 2022 - frontiersin.org
Astrocytes play key roles in the regulation of brain energy metabolism, which has a major
impact on brain functions, including memory, neuroprotection, resistance to oxidative stress …

PET imaging of neuroinflammation in Alzheimer's disease

R Zhou, B Ji, Y Kong, L Qin, W Ren, Y Guan… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …

Reactive astrogliosis: A friend or foe in the pathogenesis of Alzheimer's disease

A Kumar, IC Fontana, A Nordberg - Journal of neurochemistry, 2023 - Wiley Online Library
Astrocytes are highly efficient homeostatic glial cells playing a crucial role in optimal brain
functioning and homeostasis. Astrocytes respond to changes in brain homoeostasis …

Microglia and astrocyte function and communication: what do we know in humans?

EF Garland, IJ Hartnell, D Boche - Frontiers in neuroscience, 2022 - frontiersin.org
Microglia and astrocytes play essential roles in the central nervous system contributing to
many functions including homeostasis, immune response, blood–brain barrier maintenance …

Staging of Alzheimer's disease: past, present, and future perspectives

J Therriault, ER Zimmer, AL Benedet… - Trends in molecular …, 2022 - cell.com
For many years Alzheimer's disease (AD) was associated with the dementia stage of the
disease, the tail end of a pathophysiological process that lasts approximately two decades …

Astrocyte biomarkers in Alzheimer disease: a systematic review and meta-analysis

B Bellaver, JP Ferrari-Souza, L Uglione da Ros… - Neurology, 2021 - AAN Enterprises
Objective To perform a systematic review and meta-analysis to determine whether fluid and
imaging astrocyte biomarkers are altered in Alzheimer disease (AD). Methods PubMed and …

Milestone Review: Metabolic dynamics of glutamate and GABA mediated neurotransmission—The essential roles of astrocytes

JV Andersen, A Schousboe - Journal of Neurochemistry, 2023 - Wiley Online Library
Since it was first generally accepted that the two amino acids glutamate and GABA act as
principal neurotransmitters, several landmark discoveries relating to this function have been …

Tracking reactive astrogliosis in autosomal dominant and sporadic Alzheimer's disease with multi-modal PET and plasma GFAP

K Chiotis, C Johansson, E Rodriguez-Vieitez… - Molecular …, 2023 - Springer
Background Plasma assays for the detection of Alzheimer's disease neuropathological
changes are receiving ever increasing interest. The concentration of plasma glial fibrillary …

[PDF][PDF] Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative …

A Chaney, F Lopez-Picon, S Serrière, R Wang… - Theranostics, 2021 - hal.science
Mouse models of Alzheimer's disease (AD) are valuable but do not fully recapitulate human
AD pathology, such as spontaneous Tau fibril accumulation and neuronal loss …