Decoding post-translational modification crosstalk with proteomics
Post-translational modification (PTM) of proteins allows cells to regulate protein functions,
transduce signals and respond to perturbations. PTMs expand protein functionality and …
transduce signals and respond to perturbations. PTMs expand protein functionality and …
The functional landscape of the human phosphoproteome
Protein phosphorylation is a key post-translational modification regulating protein function in
almost all cellular processes. Although tens of thousands of phosphorylation sites have …
almost all cellular processes. Although tens of thousands of phosphorylation sites have …
Leveraging protein dynamics to identify functional phosphorylation sites using deep learning models
Accurate prediction of post-translational modifications (PTMs) is of great significance in
understanding cellular processes, by modulating protein structure and dynamics …
understanding cellular processes, by modulating protein structure and dynamics …
High-throughput functional characterization of protein phosphorylation sites in yeast
Phosphorylation is a critical post-translational modification involved in the regulation of
almost all cellular processes. However, fewer than 5% of thousands of recently discovered …
almost all cellular processes. However, fewer than 5% of thousands of recently discovered …
Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry
MA Skinnider, MO Akinlaja, LJ Foster - Nature communications, 2023 - nature.com
We present CFdb, a harmonized resource of interaction proteomics data from 411 co-
fractionation mass spectrometry (CF-MS) datasets spanning 21,703 fractions. Meta-analysis …
fractionation mass spectrometry (CF-MS) datasets spanning 21,703 fractions. Meta-analysis …
[HTML][HTML] Deciphering the functional landscape of phosphosites with deep neural network
Z Liang, T Liu, Q Li, G Zhang, B Zhang, X Du, J Liu… - Cell Reports, 2023 - cell.com
Current biochemical approaches have only identified the most well-characterized kinases
for a tiny fraction of the phosphoproteome, and the functional assignments of phosphosites …
for a tiny fraction of the phosphoproteome, and the functional assignments of phosphosites …
Glycosylation‐Related Genes Predict the Prognosis and Immune Fraction of Ovarian Cancer Patients Based on Weighted Gene Coexpression Network Analysis …
Background. Ovarian cancer (OC) is a malignancy exhibiting high mortality in female tumors.
Glycosylation is a posttranslational modification of proteins but research has failed to …
Glycosylation is a posttranslational modification of proteins but research has failed to …
Importance of protein Ser/Thr/Tyr phosphorylation for bacterial pathogenesis
Protein phosphorylation regulates a large variety of biological processes in all living cells. In
pathogenic bacteria, the study of serine, threonine, and tyrosine (Ser/Thr/Tyr) …
pathogenic bacteria, the study of serine, threonine, and tyrosine (Ser/Thr/Tyr) …
The phosphorylation landscape of infection-related development by the rice blast fungus
N Cruz-Mireles, M Osés-Ruiz, P Derbyshire… - Cell, 2024 - cell.com
Many of the world's most devastating crop diseases are caused by fungal pathogens that
elaborate specialized infection structures to invade plant tissue. Here, we present a …
elaborate specialized infection structures to invade plant tissue. Here, we present a …
Molecular insights into the heat shock proteins of the human parasitic blood fluke Schistosoma mansoni
NA Aguoru, RS Kirk, AJ Walker - Parasites & Vectors, 2022 - Springer
Abstract Background Heat shock proteins (HSPs) are evolutionarily conserved proteins,
produced by cells in response to hostile environmental conditions, that are vital to organism …
produced by cells in response to hostile environmental conditions, that are vital to organism …