A century-long journey from the discovery of insulin to the implantation of stem cell–derived islets

A Ramzy, PJ Belmonte, MJS Braam, S Ida… - Endocrine …, 2023 - academic.oup.com
For the past century, insulin injections have saved millions of lives, but glycemic instability is
still a persistent challenge for people with diabetes, leading to tremendous morbidity and …

Bioreactor technologies for enhanced organoid culture

JP Licata, KH Schwab, YE Har-El… - International Journal of …, 2023 - mdpi.com
An organoid is a 3D organization of cells that can recapitulate some of the structure and
function of native tissue. Recent work has seen organoids gain prominence as a valuable …

Engineering 3D micro-compartments for highly efficient and scale-independent expansion of human pluripotent stem cells in bioreactors

PJR Cohen, E Luquet, J Pletenka, A Leonard, E Warter… - Biomaterials, 2023 - Elsevier
Human pluripotent stem cells (hPSCs) have emerged as the most promising cellular source
for cell therapies. To overcome the scale-up limitations of classical 2D culture systems …

Suspension culture improves iPSC expansion and pluripotency phenotype

N Cuesta-Gomez, K Verhoeff, N Dadheech… - Stem Cell Research & …, 2023 - Springer
Background Induced pluripotent stem cells (iPSCs) offer potential to revolutionize
regenerative medicine as a renewable source for islets, dopaminergic neurons, retinal cells …

Significant enhancement of fibroblast migration, invasion, and proliferation by exosomes loaded with human fibroblast growth factor 1

MD Hade, CN Suire, Z Suo - ACS Applied Materials & Interfaces, 2024 - ACS Publications
Exosomes possess several inherent properties that make them ideal for biomedical
applications, including robust stability, biocompatibility, minimal immunogenicity, and the …

Expansion of induced pluripotent stem cells under consideration of bioengineering aspects: part 2

MA Teale, SL Schneider, S Seidel… - Applied Microbiology …, 2025 - Springer
The manufacturing of allogeneic cell therapeutics based on human-induced pluripotent stem
cells (hiPSCs) holds considerable potential to revolutionize the accessibility and affordability …

Expansion of induced pluripotent stem cells under consideration of bioengineering aspects: part 1

SL Schneider, MA Teale, S Seidel… - Applied Microbiology …, 2025 - Springer
To fully utilize the potential of human induced pluripotent stem cells (hiPSCs) for allogeneic
stem cell–based therapies, efficient and scalable expansion procedures must be developed …

[HTML][HTML] Scalable expansion of iPSC and their derivatives across multiple lineages

CK Kwok, I Sébastien, K Hariharan, I Meiser… - Reproductive …, 2022 - Elsevier
Induced pluripotent stem cell (iPSC) technology enabled the production of pluripotent stem
cell lines from somatic cells from a range of known genetic backgrounds. Their ability to …

Biophysical, molecular and proteomic profiling of human retinal organoid-derived exosomes

P Arthur, S Kandoi, L Sun, A Kalvala, S Kutlehria… - Pharmaceutical …, 2023 - Springer
Purpose There is a growing interest in extracellular vesicles (EVs) for ocular applications as
therapeutics, biomarkers, and drug delivery vehicles. EVs secreted from mesenchymal stem …

Perspectives on scaling production of adipose tissue for food applications

JSK Yuen Jr, AJ Stout, NS Kawecki, SM Letcher… - Biomaterials, 2022 - Elsevier
With rising global demand for food proteins and significant environmental impact associated
with conventional animal agriculture, it is important to develop sustainable alternatives to …