Potential repurposed drug candidates for tuberculosis treatment: progress and update of drugs identified in over a decade
The devastating impact of Tuberculosis (TB) has been a menace to mankind for decades.
The World Health Organization (WHO) End TB Strategy aims to reduce TB mortality up to …
The World Health Organization (WHO) End TB Strategy aims to reduce TB mortality up to …
Inosine pranobex: a key player in the game against a wide range of viral infections and non-infectious diseases
J Sliva, CN Pantzartzi, M Votava - Advances in therapy, 2019 - Springer
Inosine pranobex (IP), commonly known as inosine acedoben dimepranol, isoprinosine and
methisoprinol, has been proven to positively impact the host's immune system, by enhancing …
methisoprinol, has been proven to positively impact the host's immune system, by enhancing …
Repurposed drug candidates for antituberculosis therapy
Q An, C Li, Y Chen, Y Deng, T Yang, Y Luo - European journal of medicinal …, 2020 - Elsevier
Antibiotics have been a key part of clinical treatments for more than 70 years. Long-term use
of antimicrobial treatments has led to the development of severe bacterial resistance, which …
of antimicrobial treatments has led to the development of severe bacterial resistance, which …
Potential anti-TB investigational compounds and drugs with repurposing potential in TB therapy: a conspectus
AA Adeniji, KE Knoll, DT Loots - Applied microbiology and biotechnology, 2020 - Springer
The latest WHO report estimates about 1.6 million global deaths annually from TB, which is
further exacerbated by drug-resistant (DR) TB and comorbidities with diabetes and HIV …
further exacerbated by drug-resistant (DR) TB and comorbidities with diabetes and HIV …
In Silico Drug Discovery Strategies Identified ADMET Properties of Decoquinate RMB041 and Its Potential Drug Targets against Mycobacterium tuberculosis
KE Knoll, MM van der Walt, DT Loots - Microbiology Spectrum, 2022 - Am Soc Microbiol
The highly adaptive cellular response of Mycobacterium tuberculosis to various antibiotics
and the high costs for clinical trials, hampers the development of novel antimicrobial agents …
and the high costs for clinical trials, hampers the development of novel antimicrobial agents …
Unlocking the enigma of phenotypic drug tolerance: mechanisms and emerging therapeutic strategies
In the ongoing battle against antimicrobial resistance, phenotypic drug tolerance poses a
formidable challenge. This adaptive ability of microorganisms to withstand drug pressure …
formidable challenge. This adaptive ability of microorganisms to withstand drug pressure …
Metabolic Rewiring of Mycobacterium tuberculosis upon Drug Treatment and Antibiotics Resistance
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a significant global
health challenge, further compounded by the issue of antimicrobial resistance (AMR). AMR …
health challenge, further compounded by the issue of antimicrobial resistance (AMR). AMR …
Screening repurposed antiviral small molecules as antimycobacterial compounds by a lux-based phoP promoter-reporter platform
The emergence of multidrug-resistant strains and hyper-virulent strains of Mycobacterium
tuberculosis are big therapeutic challenges for tuberculosis (TB) control. Repurposing …
tuberculosis are big therapeutic challenges for tuberculosis (TB) control. Repurposing …
The prospect of repurposing immunomodulatory drugs for adjunctive chemotherapy against tuberculosis: A critical review
C Lee, S Bhakta - Antibiotics, 2021 - mdpi.com
Tuberculosis (TB) remains a global health emergency, with an estimated 2 billion people
infected across the world, and 1.4 million people dying to this disease every year. Many …
infected across the world, and 1.4 million people dying to this disease every year. Many …
Tuberculosis: Experimental Models, Innovations, and Challenges
SS Jhamb, RP Singh, PP Singh - Recent Advances in Pharmaceutical …, 2023 - Springer
Tuberculosis (TB) is among the top ten killer diseases and remains the number one cause of
death due to infection. A major bottleneck in TB research remains the availability of suitable …
death due to infection. A major bottleneck in TB research remains the availability of suitable …