Glucocorticoids are steroid hormones that regulate multiple aspects of glucose homeostasis.
Glucocorticoids promote gluconeogenesis in liver, whereas in skeletal muscle and white …

Liver fibrosis is a strong predictor of long-term mortality in individuals with metabolic-
associated fatty liver disease; yet, the mechanisms underlying the progression from the …

Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity,
which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein …

Processes like cellular senescence are characterized by complex events giving rise to
heterogeneous cell populations. However, the early molecular events driving this cascade …

Mammalian chromosomes are three-dimensional entities shaped by converging and
opposing forces. Mitotic cell division induces marked chromosome condensation, but …

How spatial chromosome organization influences genome integrity is still poorly understood.
Here, we show that DNA double-strand breaks (DSBs) mediated by topoisomerase 2 (TOP2) …

Abstract The Warner-Bratzler shear force (WBSF) and myofibrillar fragmentation index (MFI)
are complementary methodologies used to measure beef tenderness. Longissimus thoracis …

Abstract β-Adrenergic signaling is a core regulator of brown adipocyte function stimulating
both lipolysis and transcription of thermogenic genes, thereby expanding the capacity for …

Fasting metabolism and immunity are tightly linked; however, it is largely unknown how
immune cells contribute to metabolic homeostasis during fasting in healthy subjects. Here …

Activation of energy expenditure in thermogenic fat is a promising strategy to improve
metabolic health, yet the dynamic processes that evoke this response are poorly …