Nanomaterials possess unique features which make them particularly attractive for
biosensing applications. In particular, carbon nanotubes (CNTs) can serve as scaffolds for …

In the last 10 years green fluorescent protein (GFP) has changed from a nearly unknown
protein to a commonly used tool in molecular biology, medicine, and cell biology. GFP is …

The KRAS oncogene product is considered a major target in anticancer drug discovery,,.
However, direct interference with KRAS signalling has not yet led to clinically useful …

Changing the data representation from the classical time delay histogram to the phasor
representation provides a global view of the fluorescence decay at each pixel of an image …

A recent development in biomedical imaging is the non-invasive mapping of molecular
events in intact tissues using fluorescence. Underpinning to this development is the …

Cell‐surface receptors acquire information from the extracellular environment and
coordinate intracellular responses. Many receptors do not operate as individual entities, but …

We identify a role for the GDI-like solubilizing factor (GSF) PDEδ in modulating signalling
through Ras family G proteins by sustaining their dynamic distribution in cellular …

Systematic efforts are under way to develop novel technologies that would allow molecular
sensing in intact organisms in vivo. Using near-infrared fluorescent molecular beacons and …

Binding of hormones, growth factors and other cell modulators to cell-surface receptors
triggers a complex array of signal-transduction events. The activation of many receptors also …

Understanding gene expression control requires defining the molecular and cellular basis of
mRNA turnover. We have previously shown that the human decapping factors hDcp2 and …