Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to
regulate proliferation, differentiation, adhesion, migration, and other functions in many cell …

Colorectal cancer is one of the most common tumors, and genetic predisposition is one of
the key risk factors in the development of this malignancy. Lynch syndrome and familial …

The gastrointestinal hamartomatous polyposis syndromes are rare, autosomal dominant
disorders associated with an increased risk of benign and malignant intestinal and …

Around 10% to 16% 1–4 of all individuals with colorectal cancer have a pathogenic variant
in a cancer susceptibility gene (Table 1). While not all of these genes have been associated …

Abstract The European Society for Paediatric Gastroenterology, Hepatology and Nutrition
(ESPGHAN) Polyposis Working Group developed recommendations to assist clinicians and …

SMAD4 is the only common SMAD in TGF-β signaling that usually impedes immune cell
activation in the tumor microenvironment. However, we demonstrated here that selective …

Background and Aims The true rate of gastric cancer (GC) in juvenile polyposis syndrome
(JPS) is unknown because of its rarity and ascertainment bias in published literature. To …

Gastrointestinal (GI) polyposis and cancer in pediatric patients is frequently due to an
underlying hereditary cancer risk syndrome requiring ongoing cancer screening …

Juvenile polyposis syndrome (JPS) is a clinically diagnosed hamartomatous polyposis
syndrome that increases the risk of gastrointestinal cancer. Approximately 40%–50% of JPS …

The hamartomatous polyposis syndromes are a set of clinically distinct disorders
characterized by the occurrence of hamartomatous polyps in the gastrointestinal tract. These …