Neuronal subtype specification in the vertebrate neural tube is one of the best-studied
examples of embryonic pattern formation. Distinct neuronal subtypes are generated in a …

Several families of extracellular guidance cues have been implicated in guiding neurons
and axons to their appropriate destinations in the nervous system. Their receptors include …

Netrin-1 is an evolutionarily conserved, secreted extracellular matrix protein involved in
axon guidance at the central nervous system midline,. Netrin-1 is expressed by cells …

The secreted factor Sonic hedgehog (SHH) is both required for and sufficient to induce
multiple developmental processes, including ventralization of the CNS, branching …

Developing axons are guided to their targets by attractive and repulsive guidance cues. In
the embryonic spinal cord, the floor plate chemoattractant Netrin-1 is required to guide …

Netrin1 has been proposed to act from the floor plate (FP) as a long-range diffusible
chemoattractant for commissural axons in the embryonic spinal cord. However, netrin1 …

Dorsal commissural axons in the developing spinal cord cross the floor plate, then turn
rostrally and grow along the longitudinal axis, close to the floor plate. We used a subtractive …

Extracellular matrix (ECM) components regulate neurite outgrowth in tissue culture and in
vivo. Live imaging of phosphotyrosine (PY) signals revealed that Xenopus laevis growth …

An important model for axon pathfinding is provided by guidance of embryonic commissural
axons from dorsal spinal cord to ventral midline floor plate (FP). FP cells produce a …

The central nervous system (CNS) of higher organisms is bilaterally‐symmetric. The transfer
of information between the two sides of the nervous system occurs through commissures …