This review attempts to cover the implication of the toll-like receptors (TLRs) in controlling
immune functions with emphasis on their significance, function, regulation and expression …

NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-
testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit …

The need to optimize vaccine potency while minimizing toxicity in healthy recipients has
motivated studies of the formulation of vaccines to control how, when, and where antigens …

Checkpoint inhibitors have demonstrated efficacy in patients with recurrent or metastatic
head and neck squamous cell carcinoma (HNSCC). However, the majority of patients do not …

Synthetic carriers such as polymer and lipid particles often struggle to meet clinical
expectations. Natural particulates—that range from pathogens to mammalian cells—are …

The innate immune system constitutes the first line of defense against invading microbial
pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect …

The small regulatory RNA microRNA-21 (miR-21) plays a crucial role in a plethora of
biological functions and diseases including development, cancer, cardiovascular diseases …

The tumor suppressor PDCD4 is a proinflammatory protein that promotes activation of the
transcription factor NF-κB and suppresses interleukin 10 (IL-10). Here we found that mice …

Cancer immunotherapy is a rapidly evolving concept that has been given the tag" fifth pillar"
of cancer therapy while radiation therapy, chemotherapy, surgery and targeted therapy …

There is a growing interest in the targeting of Toll-like receptors (TLRs) for the prevention
and treatment of cancer, rheumatoid arthritis, inflammatory bowel disease and systemic …