Lactylation stabilizes DCBLD1 activating the pentose phosphate pathway to promote cervical cancer progression

Q Meng, H Sun, Y Zhang, X Yang, S Hao, B Liu… - Journal of Experimental …, 2024 - Springer
Abstract Background Discoidin, CUB, and LCCL domain-containing type I (DCBLD1) is
identified as an oncogene involved in multiple regulation of tumor progression, but specific …

The DCBLD receptor family: emerging signaling roles in development, homeostasis and disease

AM Schmoker, AM Ebert, BA Ballif - Biochemical Journal, 2019 - portlandpress.com
The d iscoidin, CUB, and L CCL d omain-containing (DCBLD) receptor family are composed
of the type-I transmembrane proteins DCBLD1 and DCBLD2 (also ESDN and CLCP1) …

CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT

MF Mohamed, K Gupta, JW Goldufsky, R Roy… - Nature …, 2022 - nature.com
Abstract Type 3 Secretion System (T3SS) is a highly conserved virulence structure that plays
an essential role in the pathogenesis of many Gram-negative pathogenic bacteria, including …

DCBLD2 regulates vascular hyperplasia by modulating the platelet derived growth factor receptor‐β endocytosis through Caveolin‐1 in vascular smooth muscle cells

S Wang, X Liu, Z Meng, Q Feng, Y Lin, H Niu… - The FASEB …, 2022 - Wiley Online Library
DCBLD2 is a neuropilin‐like transmembrane protein that is up‐regulated during arterial
remodeling in humans, rats, and mice. Activation of PDGFR‐β via PDGF triggers receptor …

Association of DCBLD2 upregulation with tumor progression and poor survival in colorectal cancer

J He, H Huang, Y Du, D Peng, Y Zhou, Y Li, H Wang… - Cellular Oncology, 2020 - Springer
Purpose DCBLD2 expression dysregulation has been reported in several types of human
cancer. As yet, however, the role of DCBLD2 in colorectal cancer (CRC) is not known …

Single nucleotide polymorphism rs6942067 is a risk factor in young and in non-smoking patients with HPV negative head and neck squamous cell carcinoma

GB Cardin, M Bernard, H Bahig, PF Nguyen-Tan… - Cancers, 2019 - mdpi.com
Genetic factors behind the increasing incidence of human papillomavirus (HPV) negative
head and neck squamous cell carcinoma (HNSCC) in young non-smokers are suspected …

Genome-wide patterns of homozygosity and relevant characterizations on the population structure in Piétrain pigs

H Zhan, S Zhang, K Zhang, X Peng, S Xie, X Li, S Zhao… - Genes, 2020 - mdpi.com
Investigating the patterns of homozygosity, linkage disequilibrium, effective population size
and inbreeding coefficients in livestock contributes to our understanding of the genetic …

DCBLD1 overexpression is associated with a poor prognosis in head and neck squamous cell carcinoma

L Fu, M Yan, MX Ma, Y Luo, M Shao, M Gosau… - Frontiers in …, 2022 - frontiersin.org
Background DCBLD1 is highly expressed in several kinds of cancer and plays a potential
prognostic factor. However, the prognostic value and immune infiltration in head and neck …

DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma

GB Cardin, M Bernard, F Rodier, A Christopoulos - Scientific Reports, 2021 - nature.com
Germline single nucleotide polymorphisms in the promoter region of the DCBLD1 gene are
associated with non-smoking cases of both non-small cell lung carcinoma (NSCLC) and …

[HTML][HTML] Identification of actionable targets for breast cancer intervention using a diversity outbred mouse model

JB Jacob, KC Wei, G Bepler, JD Reyes, A Cani, L Polin… - Iscience, 2023 - cell.com
HER2-targeted therapy has improved breast cancer survival, but treatment resistance and
disease prevention remain major challenges. Genes that enable HER2/Neu oncogenesis …