In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …

Spirocyclic scaffolds are incorporated in various approved drugs and drug candidates. The
increasing interest in less planar bioactive compounds has given rise to the development of …

Thermal C–C bond cleavage reactions allow the construction of structurally diverse
molecular skeletons via predictable and efficient bond reorganizations. Visible light …

The development of novel synthetic strategies to form new chemical entities in a
stereoselective manner is an ongoing significant objective in organic and medicinal …

Highlights•Drug-likeness refers to the similarity between compounds and drugs; drug-like
compounds are more likely to be transformed into drugs.•Chemical structures with enhanced …

A quaternary carbon bears four other carbon substituents or combination of four non-
hydrogen substituents at four vertices of a tetrahedron. The spirocyclic quaternary carbon …

Three-and four-membered rings, widespread motifs in nature and medicinal chemistry, have
fascinated chemists ever since their discovery. However, due to energetic considerations …

The development of efficient and straightforward methods for obtaining all optically active
isomers of structurally rigid spirocycles from readily available starting materials is of great …

The enantioselective synthesis of spirocycles has long been pursued by organic chemists.
Despite their unique 3D properties and presence in several natural products, the difficulty in …

Catalytic functionalization of alkynes with organoboron reagents provides a straightforward
access to stereochemically defined multisubstituted alkenes, which are structural motifs …