The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation

D Brites - Frontiers in pharmacology, 2012 - frontiersin.org
Unconjugated hyperbilirubinemia is a common condition in the first week of postnatal life.
Although generally harmless, some neonates may develop very high levels of unconjugated …

Central nervous system myeloid cells as drug targets: current status and translational challenges

K Biber, T Möller, E Boddeke, M Prinz - Nature reviews Drug discovery, 2016 - nature.com
Myeloid cells of the central nervous system (CNS), which include parenchymal microglia,
macrophages at CNS interfaces and monocytes recruited from the circulation during …

The brain's best friend: microglial neurotoxicity revisited

S Hellwig, A Heinrich, K Biber - Frontiers in cellular neuroscience, 2013 - frontiersin.org
One long standing aspect of microglia biology was never questioned; their involvement in
brain disease. Based on morphological changes (retracted processes and amoeboid shape) …

Environmental enrichment reduces adolescent anxiety-and depression-like behaviors of rats subjected to infant nerve injury

X Gong, Y Chen, J Chang, Y Huang, M Cai… - Journal of …, 2018 - Springer
Background Infant nerve injury causes delayed adolescent neuropathic pain, but whether it
also leads to psychiatric illness is unknown. Environmental enrichment (EE) increases social …

Edible bird's nest ameliorates oxidative stress-induced apoptosis in SH-SY5Y human neuroblastoma cells

MY Yew, RY Koh, SM Chye, I Othman… - BMC complementary and …, 2014 - Springer
Background Parkinson's disease (PD) is the second most common neurodegenerative
disorder affecting the senile population with manifestation of motor disability and cognitive …

Non-canonical programmed cell death mechanisms triggered by natural compounds

M Diederich, C Cerella - Seminars in cancer biology, 2016 - Elsevier
Natural compounds are the fundament of pharmacological treatments and more than 50% of
all anticancer drugs are of natural origins or at least derived from scaffolds present in Nature …

A new face for old antibiotics: tetracyclines in treatment of amyloidoses

T Stoilova, L Colombo, G Forloni… - Journal of medicinal …, 2013 - ACS Publications
The use of tetracyclines has declined because of the appearance of resistant bacterial
strains. However, the indications of nonantimicrobial activities of these drugs have …

Minocycline attenuates colistin-induced neurotoxicity via suppression of apoptosis, mitochondrial dysfunction and oxidative stress

C Dai, GD Ciccotosto, R Cappai, Y Wang… - Journal of …, 2017 - academic.oup.com
Background: Neurotoxicity is an adverse effect patients experience during colistin therapy.
The development of effective neuroprotective agents that can be co-administered during …

Attenuation of neuro-inflammation improves survival and neurodegeneration in a mouse model of severe neonatal hyperbilirubinemia

S Vodret, G Bortolussi, A Iaconcig, E Martinelli… - Brain, behavior, and …, 2018 - Elsevier
All pre-term newborns and a high proportion of term newborns develop neonatal jaundice.
Neonatal jaundice is usually a benign condition and self-resolves within few days after birth …

Oxidopamine and oxidative stress: Recent advances in experimental physiology and pharmacology

I Pantic, J Cumic, SR Skodric, S Dugalic… - Chemico-biological …, 2021 - Elsevier
Abstract Oxidopamine (6-hydroxydopamine, 6-OHDA) is a toxin commonly used for the
creation of experimental animal models of Parkinson's disease, attention-deficit hyperactivity …