The blood-brain barrier (BBB) is a critical regulator of brain homeostasis. Additionally, the
BBB is the most significant obstacle to effective CNS drug delivery. It possesses specific …

The goal of reperfusion therapy for acute ischemic stroke (AIS) is to restore cerebral blood
flow through recanalization of the occluded vessel. Unfortunately, successful recanalization …

The purpose of this study was to investigate the relationship between hyperperfusion and
hemorrhagic transformation (HT) in acute ischemic stroke (AIS). Pseudo-continuous arterial …

Futile recanalization hampers prognoses of ischemic stroke after successful mechanical
thrombectomy, hypothetically through post-recanalization perfusion deficits, onset-to-groin …

Progress in experimental stroke and translational medicine could be accelerated by high-
resolution in vivo imaging of disease progression in the mouse cortex. Here, we introduce …

Ischemic injury can be alleviated by the judicious use of hypothermia. However, the optimal
regimens and the temporal kinetics of post-stroke neurovascular responses to hypothermic …

Diffusion-weighted arterial spin labeling magnetic resonance imaging has recently been
proposed to quantify the rate of water exchange (Kw) across the blood–brain barrier in …

The blood–brain barrier (BBB) is a functional phenotype exhibited by the neurovascular unit
(NVU). It is maintained and regulated by the interaction between cellular and non-cellular …

Methylene blue (MB) has unique energy-enhancing and antioxidant properties and is FDA-
approved drug to treat methemoglobinemia and cyanide poisoning. This study evaluated the …

Methylene blue (MB) USP, which has energy-enhancing and antioxidant properties, is
currently used to treat methemoglobinemia and cyanide poisoning in humans. We recently …