The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …

Although ample evidence links hepatic lipid accumulation with hepatic insulin resistance,
the mechanistic basis of this association is incompletely understood and controversial …

Plasma free fatty acid (FFA) concentration is elevated in obesity, insulin resistance (IR), non-
alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D), and related comorbidities such …

Acyl-CoA: diacylglycerol acyltransferase (DGAT, EC 2.3. 1.20) catalyzes the last reaction in
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly …

Nonalcoholic fatty liver disease (NAFLD) encompasses a range of liver pathology ranging
from simple steatosis to varying degrees of inflammation, hepatocyte injury and fibrosis …

Nonalcoholic fatty liver disease (NAFLD) is the liver manifestation of the complex metabolic
derangements associated with obesity. NAFLD is characterized by excessive deposition of …

The liver is the central metabolic organ and plays a pivotal role in regulating homeostasis of
glucose and lipid metabolism. Aberrant liver metabolism promotes insulin resistance, which …

Nonalcoholic fatty liver disease (NAFLD) refers to a metabolic syndrome linked with type 2
diabetes mellitus, obesity, and cardiovascular diseases. It is characterized by the …