A highly diverse T-cell receptor (TCR) repertoire is a fundamental property of an effective
immune system, and is associated with efficient control of viral infections and other …

T-cell antigen receptor (TCR) variability enables the cellular immune system to discriminate
between self and non-self. High-throughput TCR sequencing (TCR-seq) involves the use of …

T and B cell receptor loci undergo combinatorial rearrangement, generating a diverse
immune receptor repertoire, which is vital for recognition of potential antigens. Here we use …

Although the fetal immune system is considered tolerogenic, preterm infants can suffer from
severe intestinal inflammation, including necrotizing enterocolitis (NEC). Here, we …

Massively parallel sequencing is a useful approach for characterizing T-cell receptor
diversity. However, immune receptors are extraordinarily difficult sequencing targets …

T cell repertoire diversity and clonotype follow-up in vaccination, cancer, infectious and
immune diseases represent a major challenge owing to the enormous complexity of the data …

Delayed T cell recovery and restricted T cell receptor (TCR) diversity after allogeneic
hematopoietic stem cell transplantation (allo-HSCT) are associated with increased risks of …

The naïve T‐cell repertoire is vast, containing millions of unique T‐cell receptor (TCR)
structures. Faced with such diversity, the mobilization of TCR structures from this enormous …

Human T cell antigen receptors (TCRs) pair in millions of combinations to create complex
and unique T cell repertoires for each person. Through the use of tetramers to analyze TCRs …

The TCR repertoire is a mirror of the human immune system that reflects processes caused
by infections, cancer, autoimmunity, and aging. Next generation sequencing (NGS) is …