Osteoporosis is a common disease characterised by a systemic impairment of bone mass
and microarchitecture that results in fragility fractures. With an ageing population, the …

Osteoclasts are multinucleated cells that are characterized by their unique ability to resorb
large quantities of bone. Therefore, they are frequently the target of therapeutic interventions …

Male osteoporosis is a still largely underdiagnosed pathological condition. As a
consequence, bone fragility in men remains undertreated mainly due to the low screening …

The past decade has brought tremendous progress in unraveling the pathophysiology of
Alzheimer's disease (AD). While increasingly sophisticated immunotherapy targeting soluble …

Eur J Clin Invest 2012; 42 (12): 1332–1341 Abstract Background Bone remodelling
maintains skeletal integrity by osteoclasts removing foci of damaged bone and osteoblasts …

Prostate cancer is a complex disease in which metastasis to the bone is the main cause of
death. Initial stages of metastasis are generally similar to those for most solid tumors; …

Introduction Despite significant progress, a disease-modifying therapy for Alzheimer's
disease (AD) has not yet been developed. Recent findings implicate soluble oligomeric …

Objective Oxidative stress (OS) is the main cause leading to diabetic renal fibrosis. Recently,
Fyn was paid much attention on OS and emerged as a pivotal player in acute kidney injury …

The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib irreversibly binds BTK at Cys481,
inhibiting its kinase activity and thus blocking transduction of B cell receptor (BCR) signaling …

Currently, no effective therapies exist for fibrodysplasia ossificans progressiva (FOP), a rare
congenital syndrome in which heterotopic bone is formed in soft tissues owing to …