A recent joint meeting was held on January 30, 2014, with the US Food and Drug
Administration (FDA), National Cancer Institute (NCI), clinical scientists, imaging experts …

Radiographic endpoints including response and progression are important for the
evaluation of new glioblastoma therapies. The current RANO criteria was developed to …

Malignant astrocytic gliomas such as glioblastoma are the most common and lethal
intracranial tumors. These cancers exhibit a relentless malignant progression characterized …

The wide variety of treatment options that exist for glioblastoma, including surgery, ionizing
radiation, anti-neoplastic chemotherapies, anti-angiogenic therapies, and active or passive …

Gliomas are the most common primary brain tumors in adults. They arise in the glial tissue
and primarily occur in the brain. Low‐grade tumors of World Health Organization (WHO) …

Purpose: Sodium fluorescein is a dye that, intravenously injected, selectively accumulates in
high-grade glioma (HGG) tissue through a damaged blood–brain barrier. In this article, the …

Little progress has been made in the treatment of gliomas during the past 25 years. One
reason is our poor understanding of the cell of origin in these tumors and of the mechanisms …

Parallel to the role that normal stem cells play in organogenesis, cancer stem cells are
thought to be crucial for tumorigenesis. Understanding normal development might therefore …

Malignant gliomas, the most common type of primary brain tumor, are a spectrum of tumors
of varying differentiation and malignancy grades. These tumors may arise from neural stem …

BACKGROUND AND PURPOSE: The MR imaging characteristics of oligodendrogliomas
and astrocytomas on spin-echo (SE), echo-planar relative cerebral blood volume (rCBV) …