Environmental enrichment (EE) is an experimental paradigm that is used to explore how a
complex, stimulating environment can impact overall health. In laboratory animal …

The overarching view of current tumor therapies simplifies cancer to a cell-biology problem
in which neoplasms are caused solely by malignant cells and the exploration of …

Several types of cancer grow differently depending on the environmental stimuli they
receive. In glioma, exposure to an enriched environment (EE) increases the overall survival …

BTBR T+ Itpr3tf/J (BTBR) mice are used as a model of autism spectrum disorder (ASD),
displaying similar behavioral and physiological deficits observed in patients with ASD. Our …

Physical and social environments influence immune homeostasis within adipose tissue, yet
the mechanisms remain poorly defined. We report that an enriched environment (EE) …

This study analyzed whether environmental enrichment (EE) modulates the nociceptive and
inflammatory responses in the mouse model of arthritis induced by Complete Freund's …

This systematic review aims to evaluate the influence of environmental enrichment (EE) on
oncological factors in experimental studies involving various types of cancer models. A …

Macroenvironmental factors, including a patient's physical and social environment, play a
role in cancer risk and progression. Our previous preclinical studies have shown that the …

While positive social-behavioral factors predict longer survival in cancer patients, the
underlying mechanisms are unknown. Since tumor metastasis are the major cancer mortality …

Limitations of pharmaceutical drugs and biologics for chronic diseases (eg, medication non-
adherence, adverse effects, toxicity, or inadequate efficacy) can be mitigated by mobile …