Despite advances in genetic and proteomic techniques, a complete portrait of the proteome
and its complement of dynamic interactions and modifications remains a lofty, and as of yet …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

The addition of O-linked-β-DN-acetylglucosamine (O-GlcNAc) onto serine and threonine
residues of nuclear and cytoplasmic proteins is an abundant, unique post-translational …

Cellular carbohydrates or glycans are critical mediators of biological function. Their
remarkably diverse structures and varied activities present exciting opportunities for …

Caspase-3 is an essential executor in apoptosis, and its activation has been regarded as a
biomarker of cell apoptosis. The development of Caspase-3-responsive multimodal probes …

Ethnopharmacological relevance Sini San (SNS) is recorded in Zhang Zhongjing's “Treatise
on Typhoids” and is used in the treatment of non-alcoholic fatty liver disease, hepatitis, and …

Protein glycosylation events that happen early in the secretory pathway are often
dysregulated during tumorigenesis. These events can be probed, in principle, by …

One of the O-GlcNAc modifications is the protection of cells against a variety of stressors that
result in cell death. Previous experiments have focused on the overall ability of O-GlcNAc to …

Glycosylation events play an invaluable role in regulating cellular processes including
enzymatic activity, immune recognition, protein stability, and cell–cell interactions. However …

O-linked N-acetylglucosamine (O-GlcNAc) is a ubiquitous post-translational modification of
proteins and is essential for cell function. Quantifying the dynamics of O-GlcNAcylation in a …