Protein folding is inherently error prone, especially in the endoplasmic reticulum (ER). Even
with an elaborate network of molecular chaperones and protein folding facilitators …

Many proteins are translocated across the endoplasmic reticulum (ER) membrane in
eukaryotes or the plasma membrane in prokaryotes. These proteins use hydrophobic signal …

Breast cancer is the most frequent malignancy in women worldwide, and triple-negative
breast cancer (TNBC) patients have the worst prognosis and highest risk of recurrence. The …

Selective autophagy of organelles is critical for cellular differentiation, homeostasis, and
organismal health. Autophagy of the ER (ER-phagy) is implicated in human neuropathy but …

Metabolic disorders have become among the most serious threats to human health, leading
to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver …

Primary immunodeficiencies (PIDs) provide researchers with unique models to understand
in vivo immune responses in general and immunity to infections in particular. In humans …

Protein N-glycosylation plays critical roles in controlling brain function, but little is known
about human brain N-glycoproteome and its alterations in Alzheimer's disease (AD). Here …

Oligosaccharyltransferase (OST) catalyzes the transfer of a high-mannose glycan onto
secretory proteins in the endoplasmic reticulum. Mammals express two distinct OST …

Misfolded proteins compromise cellular homeostasis. This is especially problematic in the
endoplasmic reticulum (ER), which is a high-capacity protein-folding compartment and …

Tissue Inhibitor of Metalloproteases 1, also known as TIMP-1, is named for its well-
established function of inhibiting the proteolytic activity of matrix metalloproteases. Given this …