Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

Synaptic activity imposes large energy demands that are met by local adenosine
triphosphate (ATP) synthesis through glycolysis and mitochondrial oxidative …

Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …

Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …

As key organelles involved in cellular metabolism, mitochondria frequently undergo
adaptive changes in morphology, components and functions in response to various …

Brain glucose metabolism, including glycolysis, the pentose phosphate pathway, and
glycogen turnover, produces ATP for energetic support and provides the precursors for the …

Background Sepsis is defined as a systemic inflammatory response to microbial infections
with multiple organ dysfunction. This study analysed untargeted metabolomics combined …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
formation of amyloid plaques implicated in neuronal death. Genetics, age, and sex are the …

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases with
motor disturbances, cognitive decline, and behavioral impairment. It is characterized by the …

Healthy aging is an ambitious aspiration for humans, but neurodegenerative disorders, such
as Alzheimer's disease (AD), strongly affect quality of life. Using an integrated omics …