Anatomy of the antibody molecule - ScienceDirect Skip to main contentSkip to article Elsevier
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One of the major challenges of molecular allergy is to predict the allergenic potential of a
protein, particularly in novel foods. Two aspects have to be distinguished: immunogenicity …

Bivalent and bispecific antibodies and their fragments have immense potential for practical
application. Here we describe the design of small antibody fragments with two antigen …

A comparative analysis of the main-chain conformation of the L1, L2, L3, H1 and H2
hypervariable regions in 17 immunoglobulin structures that have been accurately …

Rodent monoclonal antibodies have been “humanized” or “reshaped” for therapy by
transplanting the antigen-binding loops from their variable domains onto the β-sheet …

A protein docking study was performed for two classes of biomolecular complexes: six
enzyme/inhibitor and four antibody/antigen. Biomolecular complexes for which crystal …

A new dataset of 396 protein domains is developed and used to evaluate the performance of
the protein secondary structure prediction algorithms DSC, PHD, NNSSP, and PREDATOR …

Protein-protein interaction sites in complexes of known structure are characterised using a
series of parameters to evaluate what differentiates them from other sites on the protein …

The VH gene segments produce the part of the VH domains of antibodies that contains the
first two hypervariable regions. The sequences of 83 human VH segments with open …

There are now several crystal structures of antibody Fab fragments complexed to their
protein antigens. These include Fab complexes with lysozyme, two Fab complexes with …