Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
[HTML][HTML] Polyoxidovanadates' interactions with proteins: An overview
Polyoxidovanadates (POVs, previously named polyoxovanadates) are a subgroup of
polyoxidometalates (POMs, previously named polyoxometalates) with interesting …
polyoxidometalates (POMs, previously named polyoxometalates) with interesting …
Cryo-EM in drug discovery: achievements, limitations and prospects
JP Renaud, A Chari, C Ciferri, W Liu… - Nature reviews Drug …, 2018 - nature.com
Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical
technique that can be used to determine the structure of biological macromolecules and …
technique that can be used to determine the structure of biological macromolecules and …
[HTML][HTML] A structural overview of the ion channels of the TRPM family
The TRPM (transient receptor potential melastatin) family belongs to the superfamily of TRP
cation channels. The TRPM subfamily is composed of eight members that are involved in …
cation channels. The TRPM subfamily is composed of eight members that are involved in …
Structural basis for sugar perception by Drosophila gustatory receptors
Insects rely on a family of seven transmembrane proteins called gustatory receptors (GRs) to
encode different taste modalities, such as sweet and bitter. We report structures of …
encode different taste modalities, such as sweet and bitter. We report structures of …
Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants
J Yan, CP Bengtson, B Buchthal, AM Hagenston… - Science, 2020 - science.org
INTRODUCTION N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated, calcium-
permeable neurotransmitter receptors. They are fundamental to brain development, they …
permeable neurotransmitter receptors. They are fundamental to brain development, they …
Structural mechanisms of TRPM7 activation and inhibition
KD Nadezhdin, L Correia, C Narangoda… - Nature …, 2023 - nature.com
The transient receptor potential channel TRPM7 is a master regulator of the organismal
balance of divalent cations that plays an essential role in embryonic development, immune …
balance of divalent cations that plays an essential role in embryonic development, immune …
Structure of the receptor-activated human TRPC6 and TRPC3 ion channels
Q Tang, W Guo, L Zheng, JX Wu, M Liu, X Zhou… - Cell research, 2018 - nature.com
TRPC6 and TRPC3 are receptor-activated nonselective cation channels that belong to the
family of canonical transient receptor potential (TRPC) channels. They are activated by …
family of canonical transient receptor potential (TRPC) channels. They are activated by …
Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium
Transient receptor potential melastatin 2 (TRPM2) is a calcium-permeable, non-selective
cation channel that has an essential role in diverse physiological processes such as core …
cation channel that has an essential role in diverse physiological processes such as core …