X chromosome inactivation and genomic imprinting are classic epigenetic processes that
cause disease when not appropriately regulated in mammals. Whereas X chromosome …

X-chromosome inactivation (XCI) ensures dosage compensation in mammals and is a
paradigm for allele-specific gene expression on a chromosome-wide scale. Important …

INTRODUCTION Genomes are spatially organized across length scales from single base
pairs to whole chromosomes. This organization is thought to regulate gene expression and …

Females have a greater immunological advantage than men, yet they are more prone to
autoimmune disorders. The basis for this sex bias lies in the X chromosome, which contains …

X chromosome aneuploidies have long been associated with human cancers, but causality
has not been established. In mammals, X chromosome inactivation (XCI) is triggered by Xist …

Once protein-coding, the X-inactivation center (Xic) is now dominated by large noncoding
RNAs (ncRNA). X chromosome inactivation (XCI) equalizes gene expression between …

Existing recombinant adeno-associated virus (rAAV) serotypes for delivering in vivo gene
therapy treatments for human liver diseases have not yielded combined high-level human …

Mammalian chromosomes are partitioned into A/B compartments and topologically
associated domains (TADs). The inactive X (Xi) chromosome, however, adopts a distinct …

In mammals, the process of X-chromosome inactivation ensures equivalent levels of X-
linked gene expression between males and females through the silencing of one of the two …

Germ cells manifest a unique gene expression program and regain totipotency in the zygote.
Here, we perform Hi-C analysis to examine 3D chromatin organization in male germ cells …