One essential prokaryotic cell function is the transport of proteins from the cytoplasm into
other compartments of the cell, the environment, and/or other bacteria or eukaryotic cells—a …

The outer surface of many archaea and bacteria is coated with a proteinaceous surface
layer (known as an S-layer), which is formed by the self-assembly of monomeric proteins …

Clostridium difficile disease has recently increased to become a dominant nosocomial
pathogen in North America and Europe, although little is known about what has driven this …

Clostridium difficile is an emergent pathogen, and the most common cause of nosocomial
diarrhea. In an effort to understand the role of small noncoding RNAs (sRNAs) in C. difficile …

The cell wall peptidoglycan of Gram-positive bacteria functions as a surface organelle for the
transport and assembly of proteins that interact with the environment, in particular, the …

Clostridium difficile is a Gram-positive spore-forming anaerobe and a major cause of
antibiotic-associated diarrhoea. Disruption of the commensal microbiota, such as through …

The pathogenesis of Clostridium difficile, the major cause of antibiotic-associated diarrhea,
is mainly associated with the production and activities of two major toxins. In many bacteria …

Clostridium difficile is the most common cause of antibiotic-associated intestinal infections
and a significant cause of morbidity and mortality. Infection with C. difficile requires …

Metronidazole was until recently used as a first-line treatment for potentially life-threatening
Clostridioides difficile (CD) infection. Although cases of metronidazole resistance have been …

Clostridium difficile-associated disease is increasing in incidence and is costly to treat. Our
understanding of how this organism senses its entry into the host and adapts for growth in …