The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …

The vascular endothelium provides the crucial interface between the blood compartment
and tissues, and displays a series of remarkable properties that normally maintain …

The lung is a primary organ for gas exchange in mammals that represents the largest
epithelial surface in direct contact with the external environment. It also serves as a crucial …

The role of NOD‐like receptor protein 3 (NLRP3)‐mediated pyroptosis in acute lung injury
(ALI) has been well identified previously. Stimulator of interferon genes (STING) is an …

Cancer is one of the leading causes of death globally, associated with multifactorial
pathophysiological components. In particular, genetic mutations, infection or inflammation …

Endoplasmic reticulum (ER) stress and mitochondrial dysfunction play a pivotal role in the
pathological process of sepsis-induced acute lung injury (ALI). Quercetin has been proved …

Increasing lines of evidence identified that dexmedetomidine (DEX) exerted protective
effects against sepsis-stimulated acute lung injury via anti-inflammation, anti-oxidation and …

The global propagation of SARS-CoV-2 leads to an unprecedented public health
emergency. Despite that the lungs are the primary organ targeted by COVID-19, systemic …

Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing
mechanisms of regeneration and fibrogenesis directly in human tissue has been hampered …

Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …