Cells must tightly regulate their gene expression programs and yet rapidly respond to acute
biochemical and biophysical cues within their environment. This information is transmitted to …

All aspects of transcription and its regulation involve dynamic events. The basal transcription
machinery and regulatory components are dynamically recruited to their target genes, and …

Live-cell measurement of protein binding to chromatin allows probing cellular biochemistry
in physiological conditions, which are difficult to mimic in vitro. However, different studies …

The tumor suppressor p53 slides along DNA while searching for its cognate site. Central to
this process is the basic C-terminal domain, whose regulatory role and its coordination with …

The book aims to provide an introduction to mathematical models that describe the
dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for …

FoxA proteins are pioneer transcription factors, among the first to bind chromatin domains in
development and enable gene activity. The Fox DNA-binding domain structurally resembles …

The binding of nuclear proteins to chromatin in live cells has been analyzed by kinetic
modeling procedures applied to experimental data from fluorescence recovery after …

Fluorescence recovery after photobleaching (FRAP) is a versatile tool for determining
diffusion and interaction/binding properties in biological and material sciences. An …

Live-cell microscopy has highlighted that transcription factors bind transiently to chromatin
but it is not clear if the duration of these binding interactions can be modulated in response …

How site-specific transcription factors scan the genome to locate their target sites is a
fundamental question in gene regulation. The in vivo binding interactions of several different …