Strategies for modeling the complex dynamical behavior of gene/protein regulatory networks
have evolved over the last 50 years as both the knowledge of these molecular control …

Stochastic modeling has become an essential tool for studying biochemical reaction
networks. There is a growing need for user-friendly and feature-complete software for model …

Abstract Systems biology models are typically considered across a spectrum from
mechanistic to abstracted description; however, the lines between these forms of modeling …

The growth and division of eukaryotic cells are regulated by complex, multi-scale networks.
In this process, the mechanism of controlling cell-cycle progression has to be robust against …

Cell size is a key characteristic that significantly affects many aspects of cellular physiology.
There are specific control mechanisms during cell cycle to maintain the cell size within a …

Numerous challenges arise in modeling and simulation as biochemical networks are
discovered with increasing complexities and unknown mechanisms. With the improvement …

The main regulator of the cell cycle in budding yeast is a cyclin-dependent protein kinase
(Cdc28) that is constitutively expressed but periodically activated and inhited during …